CEP57

Across TCGA pan-cancer cohorts, CEP57 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CEP57 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CEP57 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CEP57 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, KIRP, and KICH are the cancer types where CEP57 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.237	0.699	.002	22	view →
KIRP	DFS	Median	II,III,IV	0.038	0.783	<.001	17	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
CESC	OS	Median	All	0.116	0.587	.025	12	view →
UCEC	DFS	Median	All	1.000	0.625	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CEP57–COAD (DFS)

Open the COAD breakdown →