CEP57

Across TCGA patient cohorts, CEP57 mutation is significantly associated with the RNA expression of many other genes, with 1,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP57-associated genes across cancer lineages are MED15P1, MIR4277, and RN7SKP59. Each is linked with CEP57 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP57-to-partner and partner-to-CEP57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED15P1 grouped by CEP57-low versus CEP57-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP57→partner) and Y-score (partner→CEP57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MED15P1 →	+0.049	+5.315	.001	.003	3	3
BRCA	MIR4277 →	+0.480	+5.175	.001	.007	3	2
BRCA	RN7SKP59 →	+0.169	+6.571	<.001	.001	3	2
BRCA	LINC02558 →	+0.102	+5.441	.007	.005	3	2
CESC	WRBP1 →	+0.221	+4.234	.001	.008	3	2
BLCA	KRTAP19-5 →	+1.652	+3.910	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,163 associations by consensus.

MED15P1 by CEP57 expression — LUAD

Explore this box plot interactively →