CEP57

Across TCGA cell cohorts, CEP57 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CEP57-associated genes across cancer lineages are KRTAP10-2, PROKR2, and ZNRF4. Each is linked with CEP57 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP57-to-partner and partner-to-CEP57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-2 grouped by CEP57-low versus CEP57-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP57→partner) and Y-score (partner→CEP57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP10-2 →	+0.092	+4.152	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PROKR2 →	+0.106	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	ZNRF4 →	+0.033	+4.209	.004	.006	3	1
UPPER_AERODIGESTIVE_TRACT	FHL5 →	+0.041	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	ATXN3L →	+0.073	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	PPP1R3A →	+0.044	+4.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

KRTAP10-2 by CEP57 expression — BLOOD_Leukemia

Explore this box plot interactively →