CEP350

Across TCGA cell cohorts, CEP350 mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP350-associated genes across cancer lineages are SPANXC, OR51J1, and OR11H6. Each is linked with CEP350 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP350-to-partner and partner-to-CEP350 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPANXC grouped by CEP350-low versus CEP350-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP350→partner) and Y-score (partner→CEP350) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPANXC →	+0.955	+4.256	<.001	.002	3	3
BLOOD_Myeloma	OR51J1 →	+0.035	+3.977	<.001	.006	3	2
PANCREAS	OR11H6 →	+0.037	+3.426	<.001	.003	3	2
PANCREAS	SUPT20HL1 →	+0.008	+4.000	<.001	<.001	3	2
URINARY_TRACT	TAS2R8 →	+0.022	+3.807	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR2W1 →	+0.013	+3.078	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

SPANXC by CEP350 expression — LUNG_SCLC

Explore this box plot interactively →