CEP295NL

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CEP295NL mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP295NL-associated genes across cancer lineages are p62 Lck ligand, Rictor_pT1135, and ASNS. Each is linked with CEP295NL in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP295NL-to-partner and partner-to-CEP295NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CEP295NL-low versus CEP295NL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP295NL→partner) and Y-score (partner→CEP295NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp62 Lck ligand →+0.387+2.594.005.00632
UCECRictor_pT1135 →-0.129-3.584.002.00232
UCECASNS →+0.497+2.321.001.03332
UCECc-Jun_pS73 →-0.133-1.700.049.04432
UCEC14-3-3_beta →-0.125-3.295.003.00931
UCECEGFR_pY1068 →-0.347-2.906.001.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

p62 Lck ligand by CEP295NL expression — UCEC

Box plot of p62 Lck ligand in CEP295NL-low vs CEP295NL-high samples in UCEC.

Explore this box plot interactively →

Exploration