CEP295

Across TCGA cell cohorts, CEP295 mutation is significantly associated with the RNA expression of many other genes, with 457 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP295-associated genes across cancer lineages are CNGA2, PFN3, and H3C11. Each is linked with CEP295 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP295-to-partner and partner-to-CEP295 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGA2 grouped by CEP295-low versus CEP295-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP295→partner) and Y-score (partner→CEP295) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CNGA2 →	+0.050	+4.357	<.001	.006	3	3
OVARY	PFN3 →	+0.049	+3.865	<.001	.001	3	3
BLOOD_Myeloma	H3C11 →	+0.416	+4.807	<.001	.006	3	2
OESOPHAGUS	PYDC1 →	+0.058	+3.392	<.001	.007	3	2
SKIN	TRIM23 →	+0.380	+3.234	.003	.004	3	2
SKIN	EGR1 →	+1.883	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

CNGA2 by CEP295 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →