Across TCGA patient cohorts, CEP290 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,881 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CEP290-associated proteins across cancer lineages are SART3, CAND1, and SRSF9. Each is linked with CEP290 in more than 5 cancer types. Because this analysis shows association rather than direction, both CEP290-to-partner and partner-to-CEP290 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP290→partner) and Y-score (partner→CEP290) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SART3 →	+0.206	+0.395	<.001	<.001	3	6
LSCC	CAND1 →	+0.266	+0.539	<.001	<.001	3	5
HNSC	SRSF9 →	+0.430	+0.651	<.001	<.001	3	5
GBM	DDX42 →	+0.296	+0.405	<.001	<.001	3	5
GBM	EFTUD2 →	+0.196	+0.361	.006	.002	2	6
GBM	LIG3 →	+0.413	+0.372	.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,881 associations by consensus.

Exploration

CEP290 survival (RNA) · tumor vs normal (RNA) · all CEP290 data types