Across TCGA patient cohorts, CEP290 protein abundance is significantly associated with the RNA expression of many other genes, with 6,185 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CEP290-associated genes across cancer lineages are SPEF1, SPATA17, and CCDC151. Each is linked with CEP290 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP290-to-partner and partner-to-CEP290 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP290→partner) and Y-score (partner→CEP290) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPEF1 →	+1.906	+0.320	<.001	.001	3	4
UCEC	SPATA17 →	+0.792	+0.313	.001	<.001	3	4
UCEC	CCDC151 →	+1.288	+0.335	<.001	<.001	3	4
LSCC	EFHC1 →	+0.454	+0.200	<.001	.002	3	4
UCEC	MARCHF10 →	+0.843	+0.327	<.001	<.001	3	3
PDAC	ZDHHC20 →	-0.657	-0.453	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,185 associations by consensus.

Exploration

CEP290 survival (RNA) · tumor vs normal (RNA) · all CEP290 data types