Across TCGA patient cohorts, CEP290 mutation is significantly associated with the RNA expression of many other genes, with 5,824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP290-associated genes across cancer lineages are FANCA, MCMBP, and RAN. Each is linked with CEP290 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP290-to-partner and partner-to-CEP290 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP290→partner) and Y-score (partner→CEP290) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCA →	+0.636	+1.436	<.001	<.001	3	4
SKCM	MCMBP →	+0.565	+3.488	.006	.002	3	4
COAD	RAN →	+0.351	+3.348	.001	.004	3	4
COAD	CENPU →	+0.765	+3.486	<.001	.002	3	4
COAD	BUB3 →	+0.387	+2.780	<.001	.002	3	4
COAD	FEN1 →	+0.544	+3.127	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,824 associations by consensus.

Exploration

CEP290 survival (RNA) · tumor vs normal (RNA) · all CEP290 data types