Across TCGA patient cohorts, CEP290 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP290-associated genes across cancer lineages are Chk2_pT68, PCNA, and Shc_pY317. Each is linked with CEP290 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP290-to-partner and partner-to-CEP290 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP290→partner) and Y-score (partner→CEP290) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk2_pT68 →	-0.165	-2.459	.027	.020	3	4
COAD	PCNA →	+0.259	+2.123	.007	.010	3	3
UCEC	Shc_pY317 →	-0.079	-1.054	.039	.025	3	3
UCEC	STAT3_pY705 →	-0.338	-1.622	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.293	+2.459	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.128	+1.082	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

CEP290 survival (RNA) · tumor vs normal (RNA) · all CEP290 data types