Across TCGA cell cohorts, CEP290 mutation is significantly associated with the mutation status of many other genes, with 6,419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP290-associated genes across cancer lineages are ZFAT, UBR4, and ITPR2. Each is linked with CEP290 in more than 5 cancer types. Because this analysis shows association rather than direction, both CEP290-to-partner and partner-to-CEP290 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP290→partner) and Y-score (partner→CEP290) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZFAT →	+4.142	+2.857	.008	.008	1	6
BREAST	UBR4 →	+3.557	+2.900	.002	.002	1	6
LARGE_INTESTINE	ITPR2 →	+1.693	+2.263	<.001	<.001	1	6
LARGE_INTESTINE	ERCC6 →	+2.278	+2.095	<.001	<.001	1	5
BLOOD_Leukemia	PAPLN →	+2.452	+2.093	.003	.003	1	5
LARGE_INTESTINE	MXRA5 →	+1.819	+2.354	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,419 associations by consensus.

Exploration

CEP290 survival (RNA) · tumor vs normal (RNA) · all CEP290 data types