CEP250-AS1

Across TCGA pan-cancer cohorts, CEP250-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CEP250-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CEP250-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CEP250-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where CEP250-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.766	0.626	<.001	145	view →
SKCM	OS	Median	All	0.403	0.279	<.001	134	view →
UCEC	OS	Median	All	0.912	0.829	.002	84	view →
LUAD	DFS	Median	All	0.843	0.738	<.001	62	view →
READ	DFS	Median	III,IV	0.592	0.192	.001	52	view →
LUSC	DFS	Median	II,III,IV	0.469	0.812	.001	39	view →
KIRC	DFS	Median	All	0.758	0.846	<.001	36	view →
LGG	DFS	Median	All	0.659	0.812	<.001	32	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	24	view →
BRCA	OS	Median	II,III,IV	0.602	0.513	.004	20	view →
ESCA	OS	Quartile	III,IV	0.752	0.394	.015	20	view →
CESC	DFS	Quartile	All	0.810	0.606	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CEP250-AS1–HNSC (DFS)

Open the HNSC breakdown →