CEP192

Across TCGA cell cohorts, CEP192 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP192-associated genes across cancer lineages are HELT, TMEM213, and OR2B11. Each is linked with CEP192 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP192-to-partner and partner-to-CEP192 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by CEP192-low versus CEP192-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP192→partner) and Y-score (partner→CEP192) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.027	+4.321	<.001	.009	3	2
BLOOD_Leukemia	TMEM213 →	+0.062	+3.491	<.001	.001	3	2
LUNG_SCLC	OR2B11 →	+0.068	+3.078	<.001	.008	3	2
PANCREAS	NEUROG1 →	+0.043	+5.614	<.001	.002	3	1
PANCREAS	SPATA31D3 →	+0.006	+5.614	<.001	.002	3	1
OESOPHAGUS	BHLHE22 →	+0.047	+3.432	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

HELT by CEP192 expression — CNS

Explore this box plot interactively →