CEP19

Across TCGA patient cohorts, CEP19 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP19-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and MAPK_pT202_Y204. Each is linked with CEP19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP19-to-partner and partner-to-CEP19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CEP19-low versus CEP19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP19→partner) and Y-score (partner→CEP19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.376	-3.000	.006	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.226	-3.169	<.001	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.724	-3.169	.004	.020	3	1
UCEC	PDCD4 →	-0.690	-3.169	.007	.020	3	1
UCEC	Tuberin →	+0.359	+2.817	.015	.036	3	1
UCEC	C-Raf_pS338 →	-0.090	-3.169	.045	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by CEP19 expression — UCEC

Explore this box plot interactively →