CEP170B

Across TCGA patient cohorts, CEP170B mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CEP170B-associated genes across cancer lineages are Cyclin-B1, eIF4E, and PCNA. Each is linked with CEP170B in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP170B-to-partner and partner-to-CEP170B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CEP170B-low versus CEP170B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP170B→partner) and Y-score (partner→CEP170B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.578	+1.807	.002	.004	3	3
UCEC	eIF4E →	+0.221	+3.713	.002	<.001	3	2
COAD	PCNA →	+0.294	+2.330	.008	.020	3	2
UCEC	Rad50 →	-0.178	-1.514	.031	.015	3	2
UCEC	STAT3_pY705 →	-0.325	-1.584	<.001	.015	3	2
UCEC	ATM →	-0.513	-2.209	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Cyclin-B1 by CEP170B expression — UCEC

Explore this box plot interactively →