CEP170

Across TCGA patient cohorts, CEP170 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP170-associated genes across cancer lineages are p62 Lck ligand, ERK2, and JNK2. Each is linked with CEP170 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEP170-to-partner and partner-to-CEP170 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CEP170-low versus CEP170-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP170→partner) and Y-score (partner→CEP170) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.441	+2.485	<.001	<.001	3	2
COAD	ERK2 →	+0.186	+3.000	.026	.035	3	2
UCEC	JNK2 →	+0.241	+1.933	<.001	.008	3	2
UCEC	MEK1 →	+0.429	+2.169	<.001	<.001	3	2
UCEC	PCNA →	+0.218	+2.807	.001	.002	3	2
UCEC	Annexin_VII →	-0.091	-1.643	.034	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

p62 Lck ligand by CEP170 expression — UCEC

Explore this box plot interactively →