CEP126

Across TCGA pan-cancer cohorts, CEP126 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CEP126 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher CEP126 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CEP126 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

LUSC, LIHC, and KIRP are the cancer types where CEP126 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Quartile	II,III,IV	0.232	0.558	.002	28	view →
LIHC	OS	Tertile	II,III,IV	0.455	0.657	.006	28	view →
KIRP	OS	Median	III,IV	0.316	0.631	.013	27	view →
SKCM	DFS	Median	All	0.256	0.151	.002	27	view →
LUAD	DFS	Quartile	III,IV	0.437	0.850	.003	26	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
PAAD	OS	Quartile	All	0.587	0.237	.004	21	view →
BLCA	OS	Quartile	All	0.556	0.776	.022	18	view →
ACC	DFS	Quartile	III,IV	0.214	0.622	.011	18	view →
BRCA	OS	Median	IV	0.774	0.321	.004	17	view →
SCLC	OS	Tertile	All	0.520	1.000	.015	15	view →
CESC	DFS	Tertile	All	0.641	0.793	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CEP126–LUSC (DFS)

Open the LUSC breakdown →