CEP112

Across TCGA patient cohorts, CEP112 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP112-associated genes across cancer lineages are JNK_pT183_Y185, AMPK_pT172, and FoxM1. Each is linked with CEP112 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP112-to-partner and partner-to-CEP112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CEP112-low versus CEP112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP112→partner) and Y-score (partner→CEP112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.160	-2.415	.002	.002	3	3
UCEC	AMPK_pT172 →	+0.333	+1.678	.010	.021	3	3
UCEC	FoxM1 →	+0.212	+1.836	.009	.001	3	2
UCEC	ATM →	-0.395	-1.794	.005	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.570	+1.867	.002	.004	3	2
UCEC	cIAP →	+0.095	+2.424	.028	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

JNK_pT183_Y185 by CEP112 expression — UCEC

Explore this box plot interactively →