CEP112

Across TCGA cell cohorts, CEP112 mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEP112-associated genes across cancer lineages are PFAS, OR1E3, and IL2. Each is linked with CEP112 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEP112-to-partner and partner-to-CEP112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFAS grouped by CEP112-low versus CEP112-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP112→partner) and Y-score (partner→CEP112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFAS →	+0.765	+3.502	.004	.001	3	2
SKIN	OR1E3 →	+0.015	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL2 →	+0.040	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	FHL5 →	+0.018	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.035	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.014	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

PFAS by CEP112 expression — LARGE_INTESTINE

Explore this box plot interactively →