CEP104

Across TCGA patient cohorts, CEP104 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEP104-associated genes across cancer lineages are ATM, ERK2, and PI3K-p85. Each is linked with CEP104 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEP104-to-partner and partner-to-CEP104 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CEP104-low versus CEP104-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEP104→partner) and Y-score (partner→CEP104) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.384	-1.459	.008	.012	3	3
UCEC	ERK2 →	+0.150	+2.222	.016	.009	3	2
UCEC	PI3K-p85 →	+0.173	+2.115	.010	.016	3	2
UCEC	PTEN →	-0.257	-2.115	.046	.016	3	2
UCEC	C-Raf →	+0.127	+3.459	.006	.005	3	2
COAD	Lck →	+0.438	+3.025	.005	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by CEP104 expression — UCEC

Explore this box plot interactively →