CENPX

Across TCGA cell cohorts, CENPX RNA expression is significantly associated with the go_rna of many other GO terms, with 4,077 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CENPX-associated GO terms across cancer lineages are Mitotic DNA replication, DNA strand elongation involved in DNA replication, and DNA replication checkpoint signaling. Each is linked with CENPX in more than 15 cancer types. Because this analysis shows association rather than direction, both CENPX-to-partner and partner-to-CENPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication grouped by CENPX-low versus CENPX-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPX→partner) and Y-score (partner→CENPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Mitotic DNA replication →	+0.197	+0.809	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.171	+1.532	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.180	+1.546	<.001	<.001	3	15
OESOPHAGUS	Thymidine biosynthetic process →	+0.205	+1.163	.002	.002	3	14
OESOPHAGUS	2'-deoxyribonucleoside biosynthetic process →	+0.205	+1.163	.002	.002	3	14
OESOPHAGUS	Pyrimidine deoxyribonucleoside biosynthetic process →	+0.205	+1.163	.002	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,077 associations by consensus.

Mitotic DNA replication by CENPX expression — PANCREAS

Explore this box plot interactively →