Across TCGA pan-cancer cohorts, CENPW RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CENPW data layer compared with 1 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CENPW RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CENPW expression acts as an unfavorable survival marker, although some lineages such as READ and LUSC show a favorable association.
KIRC, ACC, and KIRP are the cancer types where CENPW RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.