CENPV

Across TCGA pan-cancer cohorts, CENPV mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CENPV’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CENPV mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CENPV is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where CENPV tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPV mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	III,IV	−0.961	<.001	11	view →
COAD	All	All	+0.197	<.001	8	view →
HNSC	All	All	−0.262	.004	4	view →
PDAC	All	All	−0.226	.016	4	view →
LUAD	Male	III,IV	−0.487	.005	3	view →
OV	All	All	−0.711	.012	2	view →
LSCC	Female	All	−0.305	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CENPV–CCRCC

Open the CCRCC breakdown →