CENPS

Across TCGA pan-cancer cohorts, CENPS RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CENPS data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CENPS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CENPS expression acts as an unfavorable survival marker, although some lineages such as CESC and KIRP show a favorable association.

UVM, KICH, and LIHC are the cancer types where CENPS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.296	0.823	<.001	105	view →
KICH	OS	Median	All	0.722	1.000	<.001	99	view →
LIHC	OS	Tertile	All	0.587	0.783	<.001	67	view →
CESC	DFS	Median	All	0.815	0.666	.001	58	view →
SCLC	OS	Quartile	All	0.133	0.601	<.001	54	view →
LGG	DFS	Median	All	0.621	0.853	<.001	54	view →
ACC	DFS	Median	All	0.280	0.743	.001	50	view →
ESCA	DFS	Tertile	III,IV	0.264	0.595	<.001	40	view →
KIRP	OS	Median	II,III,IV	0.917	0.729	.003	36	view →
KIRC	OS	Median	All	0.717	0.534	<.001	30	view →
COAD	OS	Median	All	0.923	0.811	.008	19	view →
HNSC	OS	Quartile	All	0.442	0.777	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CENPS–UVM (DFS)

Open the UVM breakdown →