CENPQ

Across TCGA patient cohorts, CENPQ mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPQ-associated genes across cancer lineages are ERK2, JNK2, and Lck. Each is linked with CENPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPQ-to-partner and partner-to-CENPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CENPQ-low versus CENPQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPQ→partner) and Y-score (partner→CENPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.230	+3.000	.010	.036	3	1
UCEC	JNK2 →	+0.282	+2.834	.002	.034	3	1
UCEC	Lck →	+0.239	+2.584	.010	.011	3	1
UCEC	p62 Lck ligand →	+0.348	+2.179	.021	.034	3	1
UCEC	PCNA →	+0.284	+2.584	.004	.011	3	1
UCEC	PDCD4 →	-0.519	-2.584	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by CENPQ expression — UCEC

Explore this box plot interactively →