CENPQ

Across TCGA cell cohorts, CENPQ RNA expression is significantly associated with the go_rna of many other GO terms, with 3,112 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPQ-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Negative regulation of sister chromatid segregation, and Regulation of mitotic sister chromatid segregation. Each is linked with CENPQ in more than 18 cancer types. Because this analysis shows association rather than direction, both CENPQ-to-partner and partner-to-CENPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by CENPQ-low versus CENPQ-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPQ→partner) and Y-score (partner→CENPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic sister chromatid separation →	+0.167	+1.077	.001	<.001	3	19
BLOOD_Myeloma	Negative regulation of sister chromatid segregation →	+0.164	+1.312	.001	<.001	3	18
BLOOD_Myeloma	Regulation of mitotic sister chromatid segregation →	+0.152	+1.247	<.001	<.001	3	18
BLOOD_Myeloma	Negative regulation of mitotic sister chromatid segregation →	+0.164	+1.312	.001	<.001	3	18
KIDNEY	Protein localization to kinetochore →	+0.233	+1.440	<.001	<.001	3	18
BLOOD_Myeloma	Negative regulation of mitotic metaphase/anaphase transition →	+0.164	+1.312	.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Regulation of mitotic sister chromatid separation by CENPQ expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →