Across TCGA cell cohorts, CENPP mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CENPP-associated genes across cancer lineages are DMRTB1, IQCF5, and PPIAL4D. Each is linked with CENPP in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPP-to-partner and partner-to-CENPP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPP→partner) and Y-score (partner→CENPP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DMRTB1 →	+0.055	+3.347	.001	.005	3	1
LARGE_INTESTINE	IQCF5 →	+0.025	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PPIAL4D →	+0.129	+3.519	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

CENPP survival (RNA) · tumor vs normal (RNA) · all CENPP data types