CENPO

Across TCGA patient cohorts, CENPO mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPO-associated genes across cancer lineages are MIR1269B, BSNDP1, and LYZL1. Each is linked with CENPO in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPO-to-partner and partner-to-CENPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1269B grouped by CENPO-low versus CENPO-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPO→partner) and Y-score (partner→CENPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR1269B →	+0.152	+4.229	<.001	.006	3	2
BLCA	BSNDP1 →	+0.102	+4.722	<.001	.003	3	2
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	2
CESC	RNU1-17P →	+0.459	+5.103	<.001	.008	3	2
CESC	RNA5SP369 →	+0.329	+5.539	.001	.004	3	2
UCEC	RN7SL140P →	+0.133	+4.167	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

MIR1269B by CENPO expression — BLCA

Explore this box plot interactively →