CENPM

Across TCGA pan-cancer cohorts, CENPM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CENPM data layer compared with 30 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CENPM mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CENPM expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where CENPM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.700	0.929	.003	24	view →
LSCC	OS	Quartile	All	0.987	0.763	.013	19	view →
LUAD	DFS	Quartile	All	0.386	1.000	.040	4	view →
GBM	OS	Median	All	0.942	0.786	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CENPM–HNSC (OS)

Open the HNSC breakdown →