CENPM

Across TCGA pan-cancer cohorts, CENPM mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CENPM’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CENPM mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CENPM is over-expressed in tumor.

LSCC, HNSC, and LUAD are the cancer types where CENPM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+0.944	<.001	9	view →
HNSC	Male	II,III,IV	+0.561	<.001	6	view →
LUAD	All	II,III,IV	+0.859	<.001	5	view →
CCRCC	All	All	+0.640	.001	2	view →
PDAC	Female	III,IV	+0.638	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CENPM–LSCC

Open the LSCC breakdown →