CENPM

Across TCGA patient cohorts, CENPM mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPM-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MEK1. Each is linked with CENPM in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPM-to-partner and partner-to-CENPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CENPM-low versus CENPM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPM→partner) and Y-score (partner→CENPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.999	.031	.035	3	1
UCEC	ERK2 →	+0.194	+2.999	.031	.035	3	1
UCEC	MEK1 →	+0.515	+3.700	.002	.001	3	1
UCEC	NF-kB-p65_pS536 →	-0.442	-2.312	.036	.034	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.563	-3.169	.007	.019	3	1
UCEC	PDCD4 →	-0.595	-2.999	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by CENPM expression — UCEC

Explore this box plot interactively →