CENPL

Across TCGA patient cohorts, CENPL mutation is significantly associated with the RNA expression of many other genes, with 1,285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPL-associated genes across cancer lineages are MIR6853, YTHDF3-AS1, and SNRPGP17. Each is linked with CENPL in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPL-to-partner and partner-to-CENPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6853 grouped by CENPL-low versus CENPL-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPL→partner) and Y-score (partner→CENPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6853 →	+0.364	+9.057	<.001	.003	3	1
UCEC	YTHDF3-AS1 →	+0.705	+2.141	<.001	.003	3	1
UCEC	SNRPGP17 →	+0.249	+2.016	<.001	.001	3	1
UCEC	DOC2B →	-1.169	-2.785	<.001	.003	3	1
UCEC	ZNHIT3 →	+0.483	+2.606	<.001	<.001	3	1
UCEC	TAF9 →	+0.654	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,285 associations by consensus.

MIR6853 by CENPL expression — BRCA

Explore this box plot interactively →