CENPL

Across TCGA cell cohorts, CENPL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,200 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPL-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Regulation of mitotic sister chromatid separation, and Negative regulation of cell cycle phase transition. Each is linked with CENPL in more than 19 cancer types. Because this analysis shows association rather than direction, both CENPL-to-partner and partner-to-CENPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by CENPL-low versus CENPL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPL→partner) and Y-score (partner→CENPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.068	+1.204	.001	<.001	3	20
OESOPHAGUS	Regulation of mitotic sister chromatid separation →	+0.162	+0.767	.002	.002	3	20
BREAST	Negative regulation of cell cycle phase transition →	+0.068	+0.848	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.108	+1.201	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Metaphase chromosome alignment →	+0.122	+1.007	.001	.001	3	20
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.122	+1.399	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,200 associations by consensus.

Negative regulation of cell cycle process by CENPL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →