CENPL

Across TCGA cell cohorts, CENPL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CENPL-associated genes across cancer lineages are IQCF6, OR13C9, and DUXA. Each is linked with CENPL in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPL-to-partner and partner-to-CENPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by CENPL-low versus CENPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPL→partner) and Y-score (partner→CENPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
BLOOD_Lymphoma	OR13C9 →	+0.019	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DUXA →	+0.208	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IQCF6 by CENPL expression — LARGE_INTESTINE

Explore this box plot interactively →