CENPK

Across TCGA pan-cancer cohorts, CENPK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CENPK data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CENPK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CENPK expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and LSCC are the cancer types where CENPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.794	0.127	.024	9	view →
GBM	DFS	Tertile	All	0.618	0.269	.026	4	view →
LSCC	DFS	Quartile	All	0.855	0.342	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CENPK–LUAD (DFS)

Open the LUAD breakdown →