CENPK

Across TCGA patient cohorts, CENPK mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPK-associated genes across cancer lineages are ERK2, Lck, and p27_pT198. Each is linked with CENPK in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPK-to-partner and partner-to-CENPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CENPK-low versus CENPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPK→partner) and Y-score (partner→CENPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.212	+3.321	.036	.010	3	1
UCEC	Lck →	+0.268	+3.321	.010	.010	1	1
UCEC	p27_pT198 →	+0.153	+3.321	.006	.010	1	1
UCEC	p62 Lck ligand →	+0.534	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by CENPK expression — UCEC

Explore this box plot interactively →