CENPH

Across TCGA patient cohorts, CENPH mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPH-associated genes across cancer lineages are MEK1, Chk2, and Rad50. Each is linked with CENPH in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPH-to-partner and partner-to-CENPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CENPH-low versus CENPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPH→partner) and Y-score (partner→CENPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.398	+3.000	.037	.036	2	1
UCEC	Chk2 →	-0.257	-3.321	.036	.010	2	1
UCEC	Rad50 →	-0.321	-3.321	.011	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MEK1 by CENPH expression — UCEC

Explore this box plot interactively →