CENPH

Across TCGA cell cohorts, CENPH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,885 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CENPH-associated GO terms across cancer lineages are DNA replication initiation, Attachment of spindle microtubules to kinetochore, and Metaphase chromosome alignment. Each is linked with CENPH in more than 19 cancer types. Because this analysis shows association rather than direction, both CENPH-to-partner and partner-to-CENPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by CENPH-low versus CENPH-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPH→partner) and Y-score (partner→CENPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA replication initiation →	+0.181	+1.117	<.001	<.001	3	20
BONE	Attachment of spindle microtubules to kinetochore →	+0.154	+1.362	.006	.005	3	19
OESOPHAGUS	Metaphase chromosome alignment →	+0.108	+0.940	.009	.002	3	19
SOFT_TISSUE	Regulation of metaphase/anaphase transition of cell cycle →	+0.122	+1.151	<.001	<.001	3	19
OESOPHAGUS	Spindle elongation →	+0.273	+1.430	<.001	<.001	3	19
CNS	Meiotic cell cycle →	+0.077	+0.818	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,885 associations by consensus.

DNA replication initiation by CENPH expression — PANCREAS

Explore this box plot interactively →