CENPA

Across TCGA pan-cancer cohorts, CENPA Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CENPA data layer compared with 30 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CENPA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CENPA expression acts as an unfavorable survival marker.

KIRP, LIHC, and HNSC are the cancer types where CENPA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.148	0.904	<.001	30	view →
LIHC	DFS	Median	All	0.076	0.553	.002	24	view →
HNSC	OS	Median	All	0.235	0.686	.028	18	view →
LGG	OS	Median	All	0.295	0.811	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CENPA–KIRP (OS)

Open the KIRP breakdown →