CENPA

Across TCGA patient cohorts, CENPA protein abundance is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CENPA-associated genes across cancer lineages are CRYBB1, ARSA, and LGMN. Each is linked with CENPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPA-to-partner and partner-to-CENPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CENPA versus CRYBB1 in HNSC, with a Pearson correlation of -0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPA→partner) and Y-score (partner→CENPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CRYBB1 →	-0.630	-1.003	<.001	.008	3	1
HNSC	ARSA →	-0.819	-0.794	.009	.005	3	1
HNSC	LGMN →	-1.091	-1.078	.001	.005	3	1
HNSC	KLF5 →	+1.826	+0.889	.005	.001	3	1
HNSC	PLA2G15 →	-0.920	-1.009	.001	.005	3	1
HNSC	STAB1 →	-1.196	-0.814	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

CENPA vs CRYBB1 — HNSC

Explore this scatter interactively →