CENPA

Across TCGA patient cohorts, CENPA mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CENPA-associated genes across cancer lineages are RN7SKP181, HMGN2P26, and RNA5SP401. Each is linked with CENPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPA-to-partner and partner-to-CENPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by CENPA-low versus CENPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPA→partner) and Y-score (partner→CENPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.279	+5.133	<.001	.008	3	2
UCEC	HMGN2P26 →	+0.260	+5.299	.001	.006	3	2
UCEC	RNA5SP401 →	+0.462	+6.027	<.001	.002	3	2
HNSC	MTATP6P30 →	+0.154	+7.954	<.001	.008	3	2
UCEC	NUTF2P8 →	+0.244	+4.982	<.001	.009	3	1
HNSC	SPATA31D4 →	+0.024	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RN7SKP181 by CENPA expression — UCEC

Explore this box plot interactively →