CENPA

Across TCGA cell cohorts, CENPA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,111 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPA-associated GO terms across cancer lineages are Positive regulation of cell cycle, Regulation of nuclear division, and Microtubule cytoskeleton organization involved in mitosis. Each is linked with CENPA in more than 19 cancer types. Because this analysis shows association rather than direction, both CENPA-to-partner and partner-to-CENPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle grouped by CENPA-low versus CENPA-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPA→partner) and Y-score (partner→CENPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of cell cycle →	+0.089	+1.190	<.001	<.001	3	20
BREAST	Regulation of nuclear division →	+0.152	+1.586	<.001	<.001	3	20
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.106	+1.162	.002	.006	3	19
OVARY	Mitotic spindle elongation →	+0.226	+0.766	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.093	+1.210	<.001	<.001	3	19
KIDNEY	Chromosome localization →	+0.102	+1.016	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,111 associations by consensus.

Positive regulation of cell cycle by CENPA expression — KIDNEY

Explore this box plot interactively →