Across TCGA patient cohorts, CENATAC mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENATAC-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and Rab11. Each is linked with CENATAC in more than 1 cancer types. Because this analysis shows association rather than direction, both CENATAC-to-partner and partner-to-CENATAC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENATAC→partner) and Y-score (partner→CENATAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.216	-2.986	.026	.037	3	1
UCEC	PCNA →	+0.265	+3.000	.034	.037	3	1
UCEC	Rab11 →	-0.178	-3.000	.033	.037	3	1
UCEC	C-Raf →	+0.168	+3.000	.042	.037	3	1
UCEC	VHL →	-0.830	-3.000	.034	.037	2	1
UCEC	4E-BP1_pT37_T46 →	-0.449	-3.000	.038	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

CENATAC survival (RNA) · tumor vs normal (RNA) · all CENATAC data types