CELSR3

Across TCGA pan-cancer cohorts, CELSR3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CELSR3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CELSR3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CELSR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

KICH, UCEC, and LAML are the cancer types where CELSR3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.025	0.773	<.001	24	view →
UCEC	DFS	Median	All	0.939	0.822	.007	22	view →
LAML	DFS	Median	All	0.028	0.583	.001	8	view →
LGG	OS	Median	All	0.213	0.799	.001	7	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →
LUAD	OS	Median	All	0.535	0.840	.008	6	view →
KIRP	OS	Median	All	0.135	0.703	.046	3	view →
COAD	DFS	Median	II,III,IV	0.940	0.744	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CELSR3–KICH (DFS)

Open the KICH breakdown →