CELSR3

Across TCGA patient cohorts, CELSR3 protein abundance is significantly associated with the RNA expression of many other genes, with 500 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CELSR3-associated genes across cancer lineages are ESS2, SLC5A4, and POLDIP3. Each is linked with CELSR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CELSR3-to-partner and partner-to-CELSR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CELSR3 versus ESS2 in GBM, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR3→partner) and Y-score (partner→CELSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ESS2 →	+0.353	+0.517	.003	.001	3	1
GBM	SLC5A4 →	-0.591	-0.491	.003	.001	3	1
GBM	POLDIP3 →	+0.519	+0.606	.003	.004	3	1
GBM	PPP6R2 →	+0.437	+0.517	.008	.002	3	1
GBM	SBF1 →	+0.648	+0.603	.002	.006	3	1
GBM	TTLL1 →	+0.456	+0.498	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 500 associations by consensus.

CELSR3 vs ESS2 — GBM

Explore this scatter interactively →