CELSR3

Across TCGA patient cohorts, CELSR3 mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELSR3-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and ER-alpha. Each is linked with CELSR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both CELSR3-to-partner and partner-to-CELSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CELSR3-low versus CELSR3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR3→partner) and Y-score (partner→CELSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.543	+2.178	<.001	.001	3	6
COAD	Caspase-7-cleavedD198 →	+1.202	+1.774	<.001	.008	3	5
BLCA	ER-alpha →	-0.181	-1.874	.020	.049	3	4
SKCM	c-Kit →	-0.501	-1.222	.018	.033	3	4
COAD	FASN →	+0.397	+2.115	.002	.017	3	4
COAD	GAPDH →	+0.583	+2.334	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

ASNS by CELSR3 expression — COAD

Explore this box plot interactively →