CELSR3

Across TCGA cell cohorts, CELSR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,070 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CELSR3-associated GO terms across cancer lineages are Serotonergic neuron axon guidance, Response to flavonoid, and UV-damage excision repair. Each is linked with CELSR3 in more than 14 cancer types. Because this analysis shows association rather than direction, both CELSR3-to-partner and partner-to-CELSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serotonergic neuron axon guidance grouped by CELSR3-low versus CELSR3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR3→partner) and Y-score (partner→CELSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Serotonergic neuron axon guidance →	+1.327	+1.537	<.001	.002	3	15
OVARY	Response to flavonoid →	+0.209	+1.666	<.001	<.001	3	10
LARGE_INTESTINE	UV-damage excision repair →	+0.069	+1.103	<.001	<.001	3	9
BLOOD_Lymphoma	Dopaminergic neuron axon guidance →	+0.404	+1.672	<.001	<.001	3	8
OVARY	Leukocyte mediated immunity →	-0.071	-1.240	<.001	.002	3	8
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.068	+0.955	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,070 associations by consensus.

Serotonergic neuron axon guidance by CELSR3 expression — URINARY_TRACT

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