CELSR3

Across TCGA cell cohorts, CELSR3 mutation is significantly associated with the RNA expression of many other genes, with 1,996 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CELSR3-associated genes across cancer lineages are LYG1, MSH4, and TLE2. Each is linked with CELSR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CELSR3-to-partner and partner-to-CELSR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by CELSR3-low versus CELSR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR3→partner) and Y-score (partner→CELSR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+1.128	+2.458	<.001	<.001	3	4
LARGE_INTESTINE	MSH4 →	+0.267	+2.564	<.001	<.001	3	4
OVARY	TLE2 →	+1.337	+3.169	.003	.005	3	3
BLOOD_Leukemia	PRSS53 →	+0.460	+2.204	.003	.005	3	3
LARGE_INTESTINE	CEP85 →	+0.563	+1.949	.007	.002	3	3
LARGE_INTESTINE	THAP9 →	+0.514	+2.458	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,996 associations by consensus.

LYG1 by CELSR3 expression — LARGE_INTESTINE

Explore this box plot interactively →