CELSR2

Across TCGA pan-cancer cohorts, CELSR2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CELSR2 data layer compared with 26 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CELSR2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CELSR2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where CELSR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.929	0.363	.001	55	view →
GBM	DFS	Tertile	All	0.866	0.698	.014	7	view →
CCRCC	DFS	Quartile	All	1.000	0.851	.036	4	view →
LUAD	DFS	Quartile	All	0.854	0.993	.029	4	view →
UCEC	OS	Quartile	All	1.000	0.816	.032	4	view →
HNSC	DFS	Median	II,III,IV	0.974	0.891	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CELSR2–LSCC (DFS)

Open the LSCC breakdown →