CELSR2

Across TCGA patient cohorts, CELSR2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,976 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CELSR2-associated genes across cancer lineages are SH2D2A, ATP8B1, and MRRF. Each is linked with CELSR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CELSR2-to-partner and partner-to-CELSR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CELSR2 versus SH2D2A in BRCA, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR2→partner) and Y-score (partner→CELSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D2A →	-1.013	-0.515	<.001	<.001	3	5
BRCA	ATP8B1 →	+1.196	+0.433	<.001	<.001	3	5
UCEC	MRRF →	+0.388	+0.370	.001	<.001	3	5
CCRCC	SLAMF8 →	-0.797	-0.316	<.001	.002	3	5
UCEC	COQ4 →	+0.577	+0.408	.002	<.001	3	5
BRCA	NXNL2 →	+1.694	+0.596	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,976 associations by consensus.

CELSR2 vs SH2D2A — BRCA

Explore this scatter interactively →